A769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator. It activates AMPK through the β subunit carbohydrate-binding module and the γ subunit but not the AMP-binding sites.A769662 stimulated partially purified rat liver AMPK with an EC50 of 0.8 µM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3.2 µM. A769662 could be a useful tool compound for both cell survival and cell proliferation.
Technical information:
| Chemical Formula: | C20H12N2O3S | |
| CAS #: | 844499-71-4 | |
| Molecular Weight: | 360.39 | |
| Purity: | >98% | |
| Appearance: | White solid or off white solid | |
| Chemical Name: | 4-hydroxy-3-(2"-hydroxy-[1,1"-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile | |
| Solubility: | Up to 50 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Scott, J.W., et al. Thienopyridone drugs are selective activators of AMP-activated protein kinase β1-containing complexes. Chem. Biol. 15: 1220-1230 (2008). |
| 2. | Cool, B., et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 3: 403-416 (2006). |
| 3. | Huang, X. et al. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J. 412:211-221 (2008). |
Other Information:
Product Specification (pdf)MSDS (pdf)
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