53AH is a selective Wnt pathway inhibitor. It is a cyclohexyl analog of IWR-1 with defined centers of chirality. In the Wnt assay, the 53AH has 5-fold greater potency in Wnt inhibition. Compared to IWR-1, 53AH is more potent at promoting stem cell differentiation into cardiomyocytes. The increase in Wnt pathway inhibition potency correlates with a 1.4-fold increase in cardiogenesis. 53AH possesses superior physicochemical properties compared to IWR-1 including improved water solubility and significantly increased chemical stability at pH = 7.4 and low cytotoxicity. Accordingly, 53AH is significantly more robust for long-term cell-based experiments and potency in cardiogenesis because of its superior chemical properties.

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

Other Information:

Product Specification (pdf)MSDS (pdf)

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