Cyclopamine is a naturally-occurring chemical that belongs to the group of steroidal jerveratrum alkaloids, a teratogen isolated from the corn lily (Veratrum californicum). It is a specific Inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened. Because hedgehog signaling pathway is involved in embryogenesis and cancer progression, Cyclopamine could be used as the inducer of stem cell differentiation towards definitive endoderm pancreatic islet cells, and as a modulator controlling cell proliferation, and as a drug to kill stem-like cancer cells and block tumor engraftment.
Technical information:
| Chemical Formula: | C27H41NO2 | |
| CAS #: | 4449-51-8 | |
| Molecular Weight: | 411.62 | |
| Purity: | >98% | |
| Appearance: | White solid | |
| Chemical Name: | (2"R,3S,3"R,3a"S,6aS,6bS,6"S,7a"R,11aS,11bR)-3",6",10,11b-tetramethyl-1,2,3,3a",4,4",5",6,6a,6b,6",7,7",7a",8,11,11a,11b-octadecahydro-3"H-spiro[benzo[a]fluorene-9,2"-furo[3,2-b]pyridin]-3-ol | |
| Solubility: | Up to 100 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Chen JK et al. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. (2002); 16(21):2743-8. |
| 2. | Jiang J. et al. Hedgehog signaling in development and cancer. Dev Cell. (2008) 15(6):801-12. |
| 3. | D"Amour KA et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol. (2006). 24(11): 1392-401. |
| 4. | Gallo R. et al. Hedgehog signaling during expansion of human pancreatic islet-derived precursors. Ann N Y Acad Sci. (2008) Dec;1150:43-5 |
| 5. | Matthew P. Scott. Cancer: A twist in a hedgehog"s tale. Nature(2003) 425, 780-782. |
| 6. | Eli E. Bar, et al. Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma. Stem Cells.( 2007) 25(10): 2524–2533. |
Other Information:
Product Specification (pdf)MSDS (pdf)
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