ITDts is a novel selective TGF-β pathway-selective inhibitor that inhibits TGF-β activity by selectively degrading the TGF-β2 receptor at the proteosome level. Racemic ITDts is 2-fold selective over the closely related Activin A signaling pathway. ITDts stimulates embryonic stem cells to differentiate into cardiomyocytes (IC50 0.7 µM) by degrading the receptor and inhibiting intracellular signaling. ITDts has been formulated as a salt to increase stability and improve water solubility (~0.1 mg/mL) for ease of handling. As a salt, ITDts is chemically and metabolically stable and is non-cytotoxic. ITDts can be used to study a wide range of biological questions in cellular processing and TGF-β signaling.

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

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Other Information:

Product Specification (pdf)MSDS (pdf)

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