ABT-869 (Linifanib) is an aminobenzopyrazole-based, orally available, ATP-competitive receptor tyrosine kinase inhibitor with IC50 potency against KDR, FLT1, CSF-1R, FLT3, and PDGFRb of 4 nM, 3 nM, 3 nM, 4 nM, and 66 nM, respectively. It is highly selective (> 1uM) against unrelated tyrosine kinases and serine/threonine kinases. [1] In cellular assays, ABT-689 exhibited potency against ligand-induced PDGFRbeat, KIT, and CSF-1R phosphorylation, with IC50s of 2, 31, and 10 nM, respectively.In vivo, ABT-869 is orally effective in a wide range of human xenograft models, including MV4-11, HT1080, H526, DLD-1, A431, MX-1, MDA-231, MDA-435LM, and glioma 9L. [2] ABT-869 displays antiproliferative and apoptotic effects on cancer cells dependent on mutant kinases, such as FLT3. Consequently, ABT-869 is in clinical studies for the treatment of acute myeloid leukemia (AML). [3, 4] ABT-689 has been shown to induce apoptosis through an AKT and GSK-3beta-dependent pathway, thus suggesting that combination therapies with GSK-3beta inhibitors may be a promising approach to AML treatment. [3]

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage condition: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

Other Information:

Product Specification (pdf) MSDS (pdf) Certificate of Analysis is available upon request.

Cellagen利用广泛的研究以及我们在干细胞生物学，药物化学和产品开发方面的专业知识，Cellagen长期以来一直为专业OEM产品提供世界领先的公司，为一线干细胞研究奠定了基础。

现在，Cellagen扩展了其最佳产品系列，并直接向研究界提供。Cellagen与世界领先的科学家有着密切的联系，并且始终认识到高标准科学研究的未满足需求。