AICAR is a natural metabolic intermediate of the purine biosynthetic pathway. In its monophosphate form, AICAR is a potent AMPK agonist, which at low concentrations, does not affect AMP, ADP, or ATP levels. [1] AICAR"s interacts directly with AMPK, inducing a conformational change that favors phosphorylation of the catalytic alpha subunit.AMPK is also implicated in the modulation of enzymes such as glucokinase and glycogen phosphorylase. Direct binding by AICAR to phosphofructokinase and fructose-1,6-bisphosphatase have been reported. AICAR"s interaction with HSP90 has also been studied and found to have antiproliferative effects in tumor cell lines such as PC-3, MCF-7, C6 glioma, U87MG, K-562, and CEM. [1, 2]

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage condition: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

Other Information:

Product Specification (pdf) MSDS (pdf) Certificate of Analysis is available upon request.

Cellagen利用广泛的研究以及我们在干细胞生物学，药物化学和产品开发方面的专业知识，Cellagen长期以来一直为专业OEM产品提供世界领先的公司，为一线干细胞研究奠定了基础。

现在，Cellagen扩展了其最佳产品系列，并直接向研究界提供。Cellagen与世界领先的科学家有着密切的联系，并且始终认识到高标准科学研究的未满足需求。