3-methyladenine (3MA) is a specific inhibitor of autophagy with activity against Vps34 and PI3Kg at IC50 values of 25 and 60 uM, respectively. [1] At concentrations of 5 mM, 3-methyladenine inhibits protein degradation in isolated rat hepatocytes by about 60% without any adverse effects on exogenous protein, protein synthesis, or intracellular ATP levels. [2]3-methyladenine was shown in time-dependent studies to inhibit class I and class III PI3K in different manners when compared to wortmannin. [3] In an inflammation model setting, 3-methyladenine was found to enhance LPS-induced NF-kB activation and production of TNF-a, iNOS, COX-2, IL-1b, and IL-12. Through the inhibition of Akt by way of class I PI3K interference, 3-methyladenine can positively regulate p38, JNK, and p65, while negatively regulate TBK1 and IFN regulatory factor 3. [4]

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage condition: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

Other Information:

Product Specification (pdf) MSDS (pdf) Certificate of Analysis is available upon request.

Cellagen利用广泛的研究以及我们在干细胞生物学，药物化学和产品开发方面的专业知识，Cellagen长期以来一直为专业OEM产品提供世界领先的公司，为一线干细胞研究奠定了基础。

现在，Cellagen扩展了其最佳产品系列，并直接向研究界提供。Cellagen与世界领先的科学家有着密切的联系，并且始终认识到高标准科学研究的未满足需求。