DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. Since the Notch pathway is involved in the development of both the nervous system and pancreas, DAPT may be useful in modulating Notch activity in embryonic stem cell differentiation studies.
Technical information:
Chemical Formula: | C23H26F2N2O4 | |
CAS #: | 208255-80-5 | |
Molecular Weight: | 432.46 | |
Purity: | >98% | |
Appearance: | White solid | |
Chemical Name: | N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine-1,1-dimethylethyl ester | |
Solubility: | Up to 35 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
1. | Dovey, HF. et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81. |
2. | Crawford, T. and Roelink, H. (2007) The Notch Response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of Sonic Hedgehog Signaling. Dev Dyn. 2007 Mar;236(3):886-92. |
Other Information:
Product Specification (pdf)MSDS (pdf)
Cellagen利用广泛的研究以及我们在干细胞生物学,药物化学和产品开发方面的专业知识,Cellagen长期以来一直为专业OEM产品提供世界领先的公司,为一线干细胞研究奠定了基础。
现在,Cellagen扩展了其最佳产品系列,并直接向研究界提供。Cellagen与世界领先的科学家有着密切的联系,并且始终认识到高标准科学研究的未满足需求。