ProductDescription
DaunorubicinisananthracyclinedrugusedthatkillingcellsbyinhibitingDNAandRNAsynthesis.ItintercalatesbetweenbasepairsandinteractswithtopoisomeraseII,thereforeinhibitingDNAreplicationandrepairandRNAsynthesis.DaunorubicinwasinitiallyisolatedfromStreptomycespeucetius.
Invitro,daunorubicininhibitstheproliferationofvarioustumorcellsatmicromolarlevel.(1)Clinically,ithasbeenusedintreatingcertaintypesofacuteleukemiaandneuroblastoma.
Technicalinformation:
| ChemicalFormula: | C27H29NO10.HCl | |
| CAS#: | 23541-50-6 | |
| MolecularWeight: | 563.98 | |
| Purity: | >98% | |
| Appearance: | orangered | |
| ChemicalName: | (8S,10S)-8-acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione,monohydrochloride | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | Daunorubicinhydrochloride |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | GewirtzDA,Acriticalevaluationofthemechanismsofactionproposedfortheantitumoreffectsoftheanthracyclineantibioticsadriamycinanddaunorubicin.BiochemPharmacol.1999;57(7):727-41.PubmedID:10075079 |
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