TMP195 is the most potent and selective class IIa HDAC inhibitor identified to date, with IC50s of 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. It has over 100-fold selectivity targeting other HDACs (IC50s>10 µM). TMP195 has an unprecedented zinc-binding group, trifluoromethyloxadiazole (TFMO), which circumvents the selectivity and pharmacologic liabilities of hydroxamates. (1)TMP195 alters the gene expression of monocytes upon treatment of colony-stimulating factors, while showing no cytotoxicity towards T cell, B cells and monocytes. This tool compound help revealed the unique cellular activities of class IIa HDACs. (1) The discovery of TMP195 and related compounds provides an alternative design for targeting metalloenzymes than the conventional chelating metal-binding group, and suggests a therapeutic potential for class IIa HDAC inhibitors distinct in mechanism and application compared to current HDAC inhibitors (e.g. Trichostatin A, or TSA).

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage condition: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

Other Information:

Product Specification (pdf) MSDS (pdf) Certificate of Analysis is available upon request.

Cellagen利用广泛的研究以及我们在干细胞生物学，药物化学和产品开发方面的专业知识，Cellagen长期以来一直为专业OEM产品提供世界领先的公司，为一线干细胞研究奠定了基础。

现在，Cellagen扩展了其最佳产品系列，并直接向研究界提供。Cellagen与世界领先的科学家有着密切的联系，并且始终认识到高标准科学研究的未满足需求。