(-)-ITD-1 is a resolved enantiomer of ITD-1 that possesses significantly less TGF-β inhibition and cardiogenesis compared to either racemic ITD-1 or (+)-ITD-1. Compared to racemic ITD-1 or (+)-ITD-1, (-)-ITD-1 can serve as a control for non-specific effects of ITD-1. (-)-ITD-1 has been formulated as a salt to increase stability and improve water solubility (~0.1 mg/mL) for ease of handling. As a salt, (-)-ITD-1 is chemically and metabolically stable and can be used as a control in the study a wide range of biological studies in cellular processing and TGF-β signaling.
Technical information:
| Chemical Formula: | C27H29NO3 | |
| CAS #: | N/A | |
| Molecular Weight: | 415.52 | |
| Purity: | >98% | |
| Appearance: | Yellow solid | |
| Chemical Name: | ethyl 4-([1,1"-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate | |
| Solubility: | Up to 50 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Willems E, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012;11(2):242-52. PMID: 22862949 |
Other Information:
Product Specification (pdf)MSDS (pdf)
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