IWP-3 is a selective small molecule wnt inhibitor, prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. It blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. It has an IC50 of 40 nM which is 100 folds less potent than Wnt-C59, but it can still efficiently promote cardiomyocyte differentiation from human ESCs.

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

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