AZD2281 (olaparib) is phthalazinone-based PARP inhibitor with a potencies of 5 nM and 1 nM for PARP1 and PARP2, respectively. It has been shown to be efficacious in the treatment of breast cancer tumors with BRCA mutations. Specifically, BRCA2 deficient tumor cells showed the strongest differential growth inhibition upon treatment with AZD2281 when compared to BRCA2-proficient cells. [1]AZD2281 has been studied in combination therapies with platinum-based drugs and taxanes; specifically, synergistic toxicity in BRCA2-deficient cells has been shown with cisplatin. [1] AZD2281 has been shown to be a radiosensitizer in the treatment of NSCLC cells. [2]

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage condition: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

Other Information:

Product Specification (pdf) MSDS (pdf) Certificate of Analysis is available upon request.

Cellagen利用广泛的研究以及我们在干细胞生物学，药物化学和产品开发方面的专业知识，Cellagen长期以来一直为专业OEM产品提供世界领先的公司，为一线干细胞研究奠定了基础。

现在，Cellagen扩展了其最佳产品系列，并直接向研究界提供。Cellagen与世界领先的科学家有着密切的联系，并且始终认识到高标准科学研究的未满足需求。